Formaldehyde → Cyclohexylhydroxymethylphosphinic acid, n-butyl ester

Reaction equation

[CH:1]1([PH:7](=[O:13])[O:8][CH2:9][CH2:10][CH2:11][CH3:12])[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.[CH2:14]=[O:15]>>[CH:1]1([P:7]([CH2:14][OH:15])(=[O:13])[O:8][CH2:9][CH2:10][CH2:11][CH3:12])[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1

Participants

Reactant 2

HCID 712Formaldehyde

HCID 178418445HCID 178418445, compound

Product 1

HCID 53866528Cyclohexylhydroxymethylphosphinic acid, n-butyl ester

Procedure

The title compound was prepared from cyclohexylphosphinic acid, n-butyl ester and paraformaldehyde according to the method described in Procedure 31. Purification by chromatography, eluting with dichloromethane containing 5% methanol, gave an oil.

Workup

customPurification by chromatography
washeluting with dichloromethane containing 5% methanol
customgave an oil

Sources & evidence

ORD record: ord-8779dd64d7dd4ab6a8cba54d39669391
Source dataset: uspto-grants-1998_03
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US05726165

Reaction notes

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