8-Amino-1,3,4,5-tetrahydro-2H-1-benzazepin-2-one → 8-[5-Chloro-4-(2,4-difluoro-6-morpholin-4-yl-phenylamino)-pyrimidin-2-ylamino]-1,3,4,5-tetrahydro-1-benzazepin-2-one

HRID 153590Notes

Reaction equation

HRID 153590 reaction equation
[Cl:1][c:2]1[n:3][cH:4][c:5]([Cl:23])[c:6]([NH:8][c:9]2[c:10]([F:22])[cH:11][c:12]([F:21])[cH:13][c:14]2[N:15]2[CH2:16][CH2:17][O:18][CH2:19][CH2:20]2)[n:7]1.[NH2:24][c:25]1[cH:26][cH:27][c:28]2[c:29]([cH:36]1)[NH:30][C:31](=[O:35])[CH2:32][CH2:33][CH2:34]2>>[c:2]1([NH:24][c:25]2[cH:26][cH:27][c:28]3[c:29]([cH:36]2)[NH:30][C:31](=[O:35])[CH2:32][CH2:33][CH2:34]3)[n:3][cH:4][c:5]([Cl:23])[c:6]([NH:8][c:9]2[c:10]([F:22])[cH:11][c:12]([F:21])[cH:13][c:14]2[N:15]2[CH2:16][CH2:17][O:18][CH2:19][CH2:20]2)[n:7]1

Participants

3

Reactant 2

HCID 46151688-Amino-1,3,4,5-tetrahydro-2H-1-benzazepin-2-oneHCID 86634002(2,5-Dichloro-pyrimidin-4-yl)-(2,4-difluoro-6-morpholin-4-yl-phenyl)-amine

Product 1

HCID 668304208-[5-Chloro-4-(2,4-difluoro-6-morpholin-4-yl-phenylamino)-pyrimidin-2-ylamino]-1,3,4,5-tetrahydro-1-benzazepin-2-one

Sources & evidence

ORD record
ord-5ec8dcddfafe4ba6b318c3097a8ce1e5
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (9/10)

Reaction notes

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