2-Amino-5-[2-fluoro-4-(1-hydroxy-1-methylethyl)phenyl]thiophene-3-carboxamide → 5-[2-Fluoro-4-(1-hydroxy-1-methylethyl)phenyl]-2-{[6-(2-fluoro-1-morpholin-4-ylethyl)pyridin-2-yl]amino}thiophene-3-carboxamide
Reaction equation
[Br:1][c:2]1[cH:3][cH:4][cH:5][c:6]([CH:8]([CH2:9][F:10])[N:11]2[CH2:12][CH2:13][O:14][CH2:15][CH2:16]2)[n:7]1.[NH2:17][c:18]1[s:19][c:20](-[c:26]2[c:27]([F:36])[cH:28][c:29]([C:32]([CH3:33])([CH3:34])[OH:35])[cH:30][cH:31]2)[cH:21][c:22]1[C:23](=[O:24])[NH2:25]>>[c:2]1([NH:17][c:18]2[s:19][c:20](-[c:26]3[c:27]([F:36])[cH:28][c:29]([C:32]([CH3:33])([CH3:34])[OH:35])[cH:30][cH:31]3)[cH:21][c:22]2[C:23](=[O:24])[NH2:25])[cH:3][cH:4][cH:5][c:6]([CH:8]([CH2:9][F:10])[N:11]2[CH2:12][CH2:13][O:14][CH2:15][CH2:16]2)[n:7]1Participants
3
Reactant 2
Product 1
Sources & evidence
- ORD record
- ord-542e4cc22c764b4d8630cfac4cbeebfd
- Source dataset
- Training data from https://doi.org/10.1039/C8SC04228D (1/10)
Reaction notes
Loading…