Methanol → 3,5-Dimethylpiperidin-4-ol

Reaction equation

[CH2:1]([c:2]1[cH:3][cH:4][cH:5][cH:6][cH:7]1)[N:8]1[CH2:9][CH:10]([CH3:16])[CH:11]([OH:15])[CH:12]([CH3:14])[CH2:13]1.[CH3:17][OH:18].[H:19][H:20].[OH-:21].[OH-:23].[Pd+2:22]>>[NH:8]1[CH2:9][CH:10]([CH3:16])[CH:11]([OH:15])[CH:12]([CH3:14])[CH2:13]1

Participants

Reactant 5

HCID 887Methanol

HCID 961Hydroxide2×

HCID 105144Allyl(1,3-bis(2,6-diisopropylphenyl)imidazol-2-ylidene)chloropalladium(II)

HCID 230036661-Benzyl-3,5-dimethylpiperidin-4-ol

HCID 178418361HCID 178418361, compound

Product 1

HCID 219737783,5-Dimethylpiperidin-4-ol

Sources & evidence

ORD record: ord-145ef58b540346ed9f07a8d57e78129f
Source dataset: Training data from https://doi.org/10.1039/C8SC04228D (1/10)
DOI: 10.1039/C8SC04228D

Reaction notes

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