Methanol → N-(3-Chloro-phenyl)-4-hydroxy-2-methyl-2H-naphtho[2,1-e]-1,2-thiazine-3-carboxamide-1,1-dioxide

Reaction equation

[CH3:30][I:31].[CH3:32][OH:33].[Cl:3][c:4]1[cH:5][c:6]([NH:10][C:11](=[O:12])[C:13]2=[C:18]([OH:19])[c:17]3[c:16]([c:27]4[c:22]([cH:21][cH:20]3)[cH:23][cH:24][cH:25][cH:26]4)[S:15](=[O:28])(=[O:29])[NH:14]2)[cH:7][cH:8][cH:9]1.[Na+:2].[OH-:1]>>[Cl:3][c:4]1[cH:5][c:6]([NH:10][C:11](=[O:12])[C:13]2=[C:18]([OH:19])[c:17]3[c:16]([c:27]4[c:22]([cH:21][cH:20]3)[cH:23][cH:24][cH:25][cH:26]4)[S:15](=[O:28])(=[O:29])[N:14]2[CH3:30])[cH:7][cH:8][cH:9]1

Participants

Reactant 5

HCID 887Methanol

HCID 923Sodium Ion

HCID 961Hydroxide

HCID 6328Methyl iodide

HCID 54695941N-(3-chloro-phenyl)-4-hydroxy-2H-naphtho[2,1-e]1,2-thiazine-3-carboxamide-1,1-dioxide

Product 1

HCID 54695958N-(3-Chloro-phenyl)-4-hydroxy-2-methyl-2H-naphtho[2,1-e]-1,2-thiazine-3-carboxamide-1,1-dioxide

Sources & evidence

ORD record: ord-d16c5c6bee4b40e98cee9ee31d1bf09f
Source dataset: Training data from https://doi.org/10.1039/C8SC04228D (1/10)
DOI: 10.1039/C8SC04228D

Reaction notes

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