Benzene → 5-Bromo-2-(3,4-difluorophenyl)pyridine

HRID 1556511

Reaction equation

HRID 1556511 reaction equation
[Br:13][c:14]1[n:15][cH:16][c:17]([Br:20])[cH:18][cH:19]1.[CH3:21][CH2:22][OH:23].[F:1][c:2]1[cH:3][c:4]([O:9][B:10]([OH:11])[OH:12])[cH:5][cH:6][c:7]1[F:8].[Na+:24].[Na+:25].[O-:26][C:27](=[O:28])[O-:29].[cH:30]1[cH:31][cH:32][cH:33][cH:34][cH:35]1>>[F:1][c:2]1[cH:3][c:4](-[c:14]2[n:15][cH:16][c:17]([Br:20])[cH:18][cH:19]2)[cH:5][cH:6][c:7]1[F:8]

Participants

7

Reactant 6

HCID 241BenzeneHCID 702EthanolHCID 923Sodium ion2×HCID 19660Carbonate IonHCID 693532,5-DibromopyridineHCID 218696723,4-Difluorophenylboric acid

Product 1

HCID 193864195-Bromo-2-(3,4-difluorophenyl)pyridine

Sources & evidence

ORD record
ord-72732f8e3e2c4d30b982a79118f8ab7f
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (1/10)

Linked notes

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