Dichloromethane → Propargyl 2-chloro-4-trifluoromethyl-5-thiazolecarboxylate

Reaction equation

[CH2:14]([C:15]#[CH:16])[Br:17].[CH2:25]([Cl:26])[Cl:27].[CH:18]([NH:19][CH:20]([CH3:21])[CH3:22])([CH3:23])[CH3:24].[Cl:1][c:2]1[s:3][c:4]([C:11](=[O:12])[OH:13])[c:5]([C:7]([F:8])([F:9])[F:10])[n:6]1>>[Cl:1][c:2]1[s:3][c:4]([C:11](=[O:12])[O:13][CH2:16][C:15]#[CH:14])[c:5]([C:7]([F:8])([F:9])[F:10])[n:6]1

Participants

Reactant 4

HCID 6344Dichloromethane

HCID 7842Propargyl bromide

HCID 7912Diisopropylamine

HCID 132827432-Chloro-4-(trifluoromethyl)-1,3-thiazole-5-carboxylic acid

Product 1

HCID 13670344Propargyl 2-chloro-4-trifluoromethyl-5-thiazolecarboxylate

Sources & evidence

ORD record: ord-e9a29d00de9d409cb5a3a7b3b6254da4
Source dataset: Training data from https://doi.org/10.1039/C8SC04228D (1/10)
DOI: 10.1039/C8SC04228D

Reaction notes

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