Aniline → 2,6-dichloro-N-phenylpyridin-3-amine

Participants

Reaction Conditions

Reaction Steps

The reaction vessel was charged with nitrogen, BINAP (2.491 mg, 4.00 µmol) and diacetoxypalladium (0.898 mg, 4.00 µmol) were dilutet in toluene (2 ml) and flushed with nitrogen.2,6-dichloro-3-iodopyridine (0.027 g, 0.1 mmol), aniline (10.96 µl, 0.12 mmol) and cesium carbonate (0.163 g, 0.50 mmol) were weight in another flask and flushed with nitrogen. The Pd-BINAP mixture was subjoined and the reaction mixture was warmed to 120° C and stirred over night. The reaction was monitored using LC/MS. No product could be obtained.

Provenance & Evidence