Diethyl Ether → 3-Bromomethyl-4-(4-fluorophenyl)-2-isopropyl-1-oxo-1,2-dihydroisoquinoline

Reaction equation

[CH3:28][CH2:29][O:30][CH2:31][CH3:32].[F:1][c:2]1[cH:3][cH:4][c:5](-[c:8]2[c:9]([CH2:22][OH:23])[n:10]([CH:19]([CH3:20])[CH3:21])[c:11](=[O:18])[c:12]3[cH:13][cH:14][cH:15][cH:16][c:17]23)[cH:6][cH:7]1.[P:24]([Br:25])([Br:26])[Br:27]>>[F:1][c:2]1[cH:3][cH:4][c:5](-[c:8]2[c:9]([CH2:22][Br:25])[n:10]([CH:19]([CH3:20])[CH3:21])[c:11](=[O:18])[c:12]3[cH:13][cH:14][cH:15][cH:16][c:17]23)[cH:6][cH:7]1

Participants

Reactant 3

HCID 3283Diethyl Ether

HCID 24614Phosphorus tribromide

HCID 20063372HCID 20063372, compound

Product 1

HCID 200633113-Bromomethyl-4-(4-fluorophenyl)-2-isopropyl-1-oxo-1,2-dihydroisoquinoline

Sources & evidence

ORD record: ord-a180a66115674b6db64b6d3b0acc429c
Source dataset: Training data from https://doi.org/10.1039/C8SC04228D (1/10)
DOI: 10.1039/C8SC04228D

Reaction notes

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