Methanol → 4-(2-Hydroxyethyl)piperidin-4-ol

Reaction equation

[CH2:1]([c:2]1[cH:3][cH:4][cH:5][cH:6][cH:7]1)[N:8]1[CH2:9][CH2:10][C:11]([OH:14])([CH2:15][CH2:16][OH:17])[CH2:12][CH2:13]1.[CH3:18][OH:19].[OH-:20].[OH-:22].[Pd+2:21]>>[NH:8]1[CH2:9][CH2:10][C:11]([OH:14])([CH2:15][CH2:16][OH:17])[CH2:12][CH2:13]1

Participants

Reactant 4

HCID 887Methanol

HCID 961Hydroxide2×

HCID 105144Allyl(1,3-bis(2,6-diisopropylphenyl)imidazol-2-ylidene)chloropalladium(II)

HCID 28029691-Benzyl-4-(2-hydroxyethyl)piperidin-4-ol

Product 1

HCID 219359914-(2-Hydroxyethyl)piperidin-4-ol

Sources & evidence

ORD record: ord-16067f5e5bc5448eab110ce1cc752b91
Source dataset: Training data from https://doi.org/10.1039/C8SC04228D (9/10)
DOI: 10.1039/C8SC04228D

Reaction notes

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