Methanol → 1-(4,4-Dimethylpentanoyl)-4-[4-(1,2,4-oxadiazol-3-yl)pyridin-2-yl]piperazine

Reaction equation

[BH4-:30].[CH3:1][C:2]([CH2:3][CH2:4][C:5](=[O:6])[N:7]1[CH2:8][CH2:9][N:10]([c:13]2[n:14][cH:15][cH:16][c:17](-[c:19]3[n:20][o:21][c:22]([C:24]([Cl:25])([Cl:26])[Cl:27])[n:23]3)[cH:18]2)[CH2:11][CH2:12]1)([CH3:28])[CH3:29].[CH3:32][OH:33].[Na+:31]>>[CH3:1][C:2]([CH2:3][CH2:4][C:5](=[O:6])[N:7]1[CH2:8][CH2:9][N:10]([c:13]2[n:14][cH:15][cH:16][c:17](-[c:19]3[n:20][o:21][cH:22][n:23]3)[cH:18]2)[CH2:11][CH2:12]1)([CH3:28])[CH3:29]

Participants

Reactant 4

HCID 887Methanol

HCID 923Sodium Ion

HCID 28123Borohydride

HCID 666737671-(4,4-Dimethylpentanoyl)-4-{4-[5-(trichloromethyl)-1,2,4-oxadiazol-3-yl]pyridin-2-yl}piperazine

Product 1

HCID 119931891-(4,4-Dimethylpentanoyl)-4-[4-(1,2,4-oxadiazol-3-yl)pyridin-2-yl]piperazine

Sources & evidence

ORD record: ord-0c0d5e9b6d2540dfbc8211acb95b918c
Source dataset: Training data from https://doi.org/10.1039/C8SC04228D (1/10)
DOI: 10.1039/C8SC04228D

Reaction notes

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