Methanol → 4-(1-Piperidinesulfonylpiperidin-4-ylmethyl)-phenylamine

Reaction equation

[CH3:30][OH:31].[F:1][C:2]([F:3])([F:4])[C:28]([NH:5][c:6]1[cH:7][cH:8][c:9]([CH2:12][CH:13]2[CH2:14][CH2:15][N:16]([S:19](=[O:20])(=[O:21])[N:22]3[CH2:23][CH2:24][CH2:25][CH2:26][CH2:27]3)[CH2:17][CH2:18]2)[cH:10][cH:11]1)=[O:29].[OH2:32]>>[NH2:5][c:6]1[cH:7][cH:8][c:9]([CH2:12][CH:13]2[CH2:14][CH2:15][N:16]([S:19](=[O:20])(=[O:21])[N:22]3[CH2:23][CH2:24][CH2:25][CH2:26][CH2:27]3)[CH2:17][CH2:18]2)[cH:10][cH:11]1

Participants

Reactant 3

HCID 887Methanol

HCID 962Water

HCID 120943982,2,2-trifluoro-N-[4-(1-piperidinesulfonylpiperidin-4-ylmethyl)-phenyl]acetamide

Product 1

HCID 120943994-(1-Piperidinesulfonylpiperidin-4-ylmethyl)-phenylamine

Sources & evidence

ORD record: ord-1f3e36ebfe444bd6bd6c417b9b1ba697
Source dataset: Training data from https://doi.org/10.1039/C8SC04228D (1/10)
DOI: 10.1039/C8SC04228D

Reaction notes

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