HuagongsheHuagongshe Chemistry Print Report · For research reference only
5-(4-Chlorophenyl)-2-oxo-1,2-dihydropyridine-3-carbonitrile → 5-(4-Chlorophenyl)-2-hydroxypyridine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 5-(4-Chlorophenyl)-2-oxo-1,2-dihydropyridine-3-carbonitrile | HCID 2763910 | — |
| Solvent | Phosphoric Acid | HCID 1004 | — |
| Product | 5-(4-Chlorophenyl)-2-hydroxypyridine | HCID 10262372 | 75.6% |
Reaction Steps
A mixture of 3-cyano-5-(4-chlorophenyl)-2-pyridinone (4.6 g) and 85% H3PO4 (60 ml) was heated at reflux for 16 hours. The resulting mixture was cooled to room temperature, poured into ice/water and filtered yielding 3.1 g of 5-(4-chlorophenyl)-2-pyridinone as a yellow solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05726176 |
| Source dataset | uspto-grants-1998_03 |
| ORD ID | ord-1a4f37788b1a484282d9cf4c25552db7 |
| Source note | uspto-grants-1998_03 |