HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrazine hydrate (1:1) → benzyl 6-isopropyl-6,7-dihydro-1H-pyrazolo[4,3-c]pyridine-5(4H)-carboxylate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrazine hydrate (1:1) | HCID 24654 | — |
| Reactant | 4-Piperidone | HCID 33721 | — |
| Reactant | Benzyl 2-Isopropyl-4-oxopiperidine-1-carboxylate | HCID 24213826 | — |
| Reactant | Benzyl 2-(4-chlorophenyl)-4-oxopiperidine-1-carboxylate | HCID 59342393 | — |
| Reactant | HCID 178418918 | HCID 178418918 | — |
| Product | benzyl 6-isopropyl-6,7-dihydro-1H-pyrazolo[4,3-c]pyridine-5(4H)-carboxylate | HCID 68503449 | — |
Reaction Steps
Benzyl 2-isopropyl-4-oxopiperidine-1-carboxylate, prepared as described for compound 67 in Example 3 using isopropylmagnesium chloride, was formylated and treated with hydrazine hydrate as described for compound 50 in Example 1 to give benzyl 6-isopropyl-6,7-dihydro-1H-pyrazolo[4,3-c]pyridine-5(4H)-carboxylate. This compound was then deprotected and treated with 4-chlorophenylsulfonyl chloride followed by NaOH as described for compound 52 in Example 1.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07732609B2 |
| Source dataset | uspto-grants-2010_06 |
| ORD ID | ord-644b876f706048c9b1a88b5f583d5ae9 |
| Source note | uspto-grants-2010_06 |