HuagongsheHuagongshe Chemistry Print Report · For research reference only
(1S,2R)-(+)-Norephedrine → alpha-[1-(2-Imidazolin-2-ylamino)ethyl]benzyl alcohol
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | (1S,2R)-(+)-Norephedrine | HCID 4786 | — |
| Reactant | O-Xylene | HCID 7237 | — |
| Reactant | 2-Nitroamino-2-imidazoline | HCID 410042 | — |
| Solvent | Acetone | HCID 180 | — |
| Product | alpha-[1-(2-Imidazolin-2-ylamino)ethyl]benzyl alcohol | HCID 54133258 | — |
Reaction Steps
A mixture of 6.5 parts of α-(1-aminoethyl)benzyl alcohol (also known as morephedrine), 5.2 parts of 2-(nitramino)-2-imidazoline and 8 parts of xylene is stirred for 30 minutes while heating at 160°-170°C. The reaction mixture is cooled and diluted with acetone. The latter is removed in vacuo, yielding α-[1-(2-imidazolin-2-ylamino)-ethyl]benzyl alcohol as an oily residue.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US03983133 |
| Source dataset | uspto-grants-1976_09 |
| ORD ID | ord-7b3aeac0763840eb994f97a3f570e980 |
| Source note | uspto-grants-1976_09 |