HuagongsheHuagongshe Chemistry Print Report · For research reference only
Trifluoroacetic acid → 2-Methyl-5-piperazin-1-yl-quinoline
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Trifluoroacetic acid | HCID 6422 | — |
| Reactant | Tert-butyl 4-(2-methylquinolin-5-yl)piperazine-1-carboxylate | HCID 49851900 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | 2-Methyl-5-piperazin-1-yl-quinoline | HCID 49851901 | 96% |
Reaction Steps
1,1-dimethylethyl 4-(2-methyl-5-quinolinyl)-1-piperazinecarboxylate (D2) (1.1 g) in a 25% solution of trifluoroacetic acid in dichloromethane (10 mL) was stirred at r.t. under an inert atmosphere for 3 hours. The reaction mixture was concentrated under reduced pressure and desalted by means of a 20 g SCX cartridge affording the title compound in 96% yield (0.74 g).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07732600B2 |
| Source dataset | uspto-grants-2010_06 |
| ORD ID | ord-314d2ca9bbee4079b72a99444a2f8f77 |
| Source note | uspto-grants-2010_06 |