Water → N-(1-cyano-1,2-dimethylpropyl)-2,3-Dibromopropionamide

HRID 1577482

Reaction equation

HRID 1577482 reaction equation
Cl.[CH3:2][C:3]([NH2:9])([CH:6]([CH3:8])[CH3:7])[C:4]#[N:5].[OH-].[Na+].O.[Br:13][CH:14]([CH2:18][Br:19])[C:15](Cl)=[O:16]>ClCCl>[C:4]([C:3]([NH:9][C:15](=[O:16])[CH:14]([Br:13])[CH2:18][Br:19])([CH3:2])[CH:6]([CH3:8])[CH3:7])#[N:5]

Participants

6

Reactant 4

HCID 962WaterHCID 14798Sodium HydroxideHCID 867902,3-Dibromopropanoyl chlorideHCID 129454442,3-Dimethyl-2-aminobutyronitrile hydrochloride

Product 1

HCID 12945446N-(1-cyano-1,2-dimethylpropyl)-2,3-Dibromopropionamide

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent2×

Procedure

A mixture of 4.5 g (0.03 mole) of the 2,3-dimethyl-2-aminobutyronitrile hydrochloride, 4.8 g (0.06 mole) of 50% aqueous sodium hydroxide, 15 ml of dichloromethane and 15 ml of water was prepared. A second solution of 7.5 g (0.03 mole) of 2,3-dibromopropionyl chloride in 15 ml dichloromethane was added with rapid stirring to the first mixture at 10°-15° C. The mixture was then allowed to reach room temperature.

Workup

  1. customwas prepared
  2. customto reach room temperature

Sources & evidence

ORD record
ord-83032e0dcd9444a0816d283a3e1f5bfe
Source dataset
uspto-grants-1981_09
Patent number
US04288384

Linked notes

Loading…