2-Methylquinolin-5-yl trifluoromethanesulfonate → 7-Chloro-2-methyl-5-piperazin-1-ylquinoline

HRID 15781

Reaction equation

HRID 15781 reaction equation
[Cl:1][C:2]1[CH:11]=[C:10]2[C:5]([CH:6]=[CH:7][C:8]([CH3:12])=[N:9]2)=[C:4](O)[CH:3]=1.FC(F)(F)S(OC1C=CC=C2C=1C=CC(C)=N2)(=O)=O.CC1C=CC2C(=CC=CC=2[N:44]2[CH2:49][CH2:48][N:47](C(OC(C)(C)C)=O)[CH2:46][CH2:45]2)N=1.CC1C=CC2C(=CC=CC=2N2CCNCC2)N=1>>[Cl:1][C:2]1[CH:11]=[C:10]2[C:5]([CH:6]=[CH:7][C:8]([CH3:12])=[N:9]2)=[C:4]([N:44]2[CH2:49][CH2:48][NH:47][CH2:46][CH2:45]2)[CH:3]=1

Participants

5

Reactant 4

HCID 498518992-Methylquinolin-5-yl trifluoromethanesulfonateHCID 49851900Tert-butyl 4-(2-methylquinolin-5-yl)piperazine-1-carboxylateHCID 498519012-Methyl-5-piperazin-1-yl-quinolineHCID 1355530187-chloro-2-methyl-5-Quinolinol

Product 1

HCID 574442757-Chloro-2-methyl-5-piperazin-1-ylquinoline

Procedure

The title compound was prepared from 7-chloro-5-hydroxy-2-methylquinoline (WO/0234754) using similar procedures to descriptions D1, D2 and D3.

Sources & evidence

ORD record
ord-13294da39753479ab5e595d8d3b068b3
Source dataset
uspto-grants-2010_06
Patent number
US07732600B2

Linked notes

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