4-n-Propylthiophenol → 6-(4-Methyl-1-piperazinyl)-2-phenyl-4-(4-propylphenylthio)pyrimidine

HRID 1578990Notes

Reaction equation

HRID 1578990 reaction equation
Cl[C:2]1[CH:7]=[C:6]([N:8]2[CH2:13][CH2:12][N:11]([CH3:14])[CH2:10][CH2:9]2)[N:5]=[C:4]([C:15]2[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=2)[N:3]=1.[CH2:21]([C:24]1[CH:29]=[CH:28][C:27]([SH:30])=[CH:26][CH:25]=1)[CH2:22][CH3:23]>>[CH3:14][N:11]1[CH2:12][CH2:13][N:8]([C:6]2[N:5]=[C:4]([C:15]3[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=3)[N:3]=[C:2]([S:30][C:27]3[CH:28]=[CH:29][C:24]([CH2:21][CH2:22][CH3:23])=[CH:25][CH:26]=3)[CH:7]=2)[CH2:9][CH2:10]1

Participants

3

Reactant 2

HCID 27604894-n-PropylthiophenolHCID 215573834-Chloro-6-(4-methyl-1-piperazinyl)-2-phenylpyrimidine

Product 1

HCID 215574476-(4-Methyl-1-piperazinyl)-2-phenyl-4-(4-propylphenylthio)pyrimidine

Procedure

Similarly, 4-chloro-6-(4-methyl-1-piperazinyl)-2-phenylpyrimidine is reacted with p-propylthiophenol to afford 6-(4-methyl-1-piperazinyl)-2-phenyl-4-(4-propylphenylthio)pyrimidine.

Sources & evidence

ORD record
ord-40c4c2331546411c8e1b77a0f284d7fa
Source dataset
uspto-grants-1976_02
Patent number
US03940395

Reaction notes

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