Ethanol → HCID 178481319, compound
Reaction equation
[CH3:1][N:2]1[C:6]([N+:7]([O-:9])=[O:8])=[CH:5][N:4]=[C:3]1[C:10](=[NH:14])OCC.C(O)C.[NH2:18][NH:19][C:20]([NH2:22])=[S:21]>C(O)(=O)C>[CH3:1][N:2]1[C:6]([N+:7]([O-:9])=[O:8])=[CH:5][N:4]=[C:3]1[C:10]([NH:18][NH:19][C:20]([NH2:22])=[S:21])=[NH:14]Participants
5
Reactant 3
Product 1
Reagents, catalysts & solvents 1
Procedure
To a stirred solution of ethyl 1-methyl-5-nitro-2-imidazolecarboximidate (0.198 g., 0.001 mole) in 10 ml. of absolute ethanol is added thiosemicarbazide (0.091 g., 0.001 mole) and 1 ml. of glacial acetic acid. The mixture is heated at reflux for 1 1/4 hours and is cooled in an ice bath. The orange-red solid is filtered washed and dried affording 0.173 g. of the title compound, melting point 210°-214°, dec.
Workup
- temperatureThe mixture is heated
- temperatureat reflux for 1 1/4 hours
- temperatureis cooled in an ice bath
- filtrationThe orange-red solid is filtered
- washwashed
- customdried
- customaffording 0.173 g
Sources & evidence
- ORD record
- ord-6329813f9cfa4db28a9d4784c7de66a1
- Source dataset
- uspto-grants-1976_02
- Patent number
- US03940411
Reaction notes
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