Phosphorus sulfide (P2S5) → 6-(4-Chlorophenyl)pyridazine-3-thiol
Reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[CH:9]=[CH:10][C:11](=O)[NH:12][N:13]=2)=[CH:4][CH:3]=1.P12(SP3(SP(SP(S3)(S1)=S)(=S)S2)=S)=[S:16]>N1C=CC=CC=1>[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[CH:9]=[CH:10][C:11](=[S:16])[NH:12][N:13]=2)=[CH:4][CH:3]=1Participants
4
Reactant 2
Product 1
Reagents, catalysts & solvents 1
Procedure
A mixture of 3.0 g of 6-(4-chlorophenyl)-pyridazinone, 50 ml of dry pyridine and 3.2 g of phosphorus pentasulfide was refluxed for 1 hour, evaporated to dryness and extracted with 200 ml of ether. The ether extract was washed with water (3×100 ml), brine (100 ml), dried over magnesium sulfate and evaporated to yield 3.0 g of 6-(4-chlorophenyl)-pyridazinthione as a yellow solid.
Workup
- temperaturewas refluxed for 1 hour
- customevaporated to dryness
- extractionextracted with 200 ml of ether
- extractionThe ether extract
- washwas washed with water (3×100 ml), brine (100 ml)
- dry with materialdried over magnesium sulfate
- customevaporated
Sources & evidence
- ORD record
- ord-e530c7df16024f4aae4797b4613d3ced
- Source dataset
- uspto-grants-1998_03
- Patent number
- US05726176
Reaction notes
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