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Formaldehyde → HCID 15581945, compound

HRID 1580443
Notes
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Reaction equation

HRID 1580443 reaction equation
[C:1]1([CH:7]([C:11]2[CH:16]=[CH:15][CH:14]=[CH:13][N:12]=2)[C:8]([NH2:10])=[S:9])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[CH3:17]O.[NH:19]1[CH2:24][CH2:23][O:22][CH2:21][CH2:20]1.C=O>CCCCCC>[O:22]1[CH2:23][CH2:24][N:19]([CH2:17][NH:10][C:8](=[S:9])[CH:7]([C:1]2[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=2)[C:11]2[CH:16]=[CH:15][CH:14]=[CH:13][N:12]=2)[CH2:20][CH2:21]1
ParticipantsProcedureWorkupSources & evidenceReaction notes

Participants

6

Reactant 4

HCID 712FormaldehydeHCID 887MethanolHCID 8083MorpholineHCID 3032556antigastrin

Product 1

HCID 15581945HCID 15581945, compound

Reagents, catalysts & solvents 1

HCID 8058HexaneSolvent

Procedure

2-Phenyl-2-(2-pyridyl)thioacetamide (1.14 g.) is suspended in 20 ml. of methanol. To the suspension is added 0.49 ml. of morpholine and 0.45 ml. of formalin. The mixture is heated on a steam bath until all of the materials are dissolved. The solution is then cooled and hexane is added. Concentrating to dryness and recrystallizing the residue from isopropanol gives N-morpholinomethyl-2-phenyl-2-(2-pyridyl)thioacetamide, m.p. 128°-130°C.

Workup

  1. additionTo the suspension is added 0.49 ml
  2. temperatureThe mixture is heated on a steam bath until all of the materials
  3. dissolutionare dissolved
  4. temperatureThe solution is then cooled
  5. concentrationConcentrating to dryness
  6. customrecrystallizing the residue from isopropanol

Sources & evidence

ORD record
ord-c51f960094d04297821fa0114da93350
Source dataset
uspto-grants-1976_01
DOI
10.6084/m9.figshare.5104873.v1
Patent number
US03932641

Reaction notes

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On this pageParticipantsProcedureWorkupSources & evidenceReaction notes