HCID 22723464, compound → HCID 22723455, compound
Reaction equation
C([O:8][C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][C:10]=1[C:15]1[N:16]=[CH:17][O:18][CH:19]=1)C1C=CC=CC=1>ClCCl.[Pd]>[O:18]1[CH:19]=[C:15]([C:10]2[CH:11]=[CH:12][CH:13]=[CH:14][C:9]=2[OH:8])[N:16]=[CH:17]1Participants
4
Reactant 1
Product 1
Reagents, catalysts & solvents 2
Procedure
To a solution of the oxazole from above (1.99 g, 7.92 mmol) in dichloromethane (20 ml) is added 10% palladium on carbon (1.99 g). The mixture is put under an atmosphere of hydrogen, stirred at room temperature over night, then filtered through Celite. The solvent is removed under reduced pressure to leave 2-(oxazol-4-yl)phenol (1.15 g, 90%), which is used for the next step without further purification.
Workup
- filtrationfiltered through Celite
- customThe solvent is removed under reduced pressure
Sources & evidence
- ORD record
- ord-28d2c149803b48fca9e0788fac35463b
- Source dataset
- uspto-grants-2004_05
- Patent number
- US06730792B2
Reaction notes
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