Ethylamine → 2-Ethylamino-6-methyl-3-(thiophene-2-carbonyl)pyridine

HRID 1582971

Reaction equation

HRID 1582971 reaction equation
Cl[C:2]1[C:7]([C:8]([C:10]2[S:11][CH:12]=[CH:13][CH:14]=2)=[O:9])=[CH:6][CH:5]=[C:4]([CH3:15])[N:3]=1.[CH2:16]([NH2:18])[CH3:17]>>[CH2:16]([NH:18][C:2]1[C:7]([C:8]([C:10]2[S:11][CH:12]=[CH:13][CH:14]=2)=[O:9])=[CH:6][CH:5]=[C:4]([CH3:15])[N:3]=1)[CH3:17]

Participants

3

Reactant 2

HCID 6341EthylamineHCID 227167012-Chloro-6-methyl-3-(thiophene-2-carbonyl)pyridine

Product 1

HCID 227166502-Ethylamino-6-methyl-3-(thiophene-2-carbonyl)pyridine

Procedure

In a sealed tube were heated and stirred 2-chloro-6-methyl-3-(thiophene-2-carbonyl)pyridine and a 70% ethylamine aqueous solution. Thereafter, the reaction mixture was worked up and purified in a usual manner to obtain 2-ethylamino-6-methyl-3-(thiophene-2-carbonyl)pyridine. NMR1: 7.97 (1H, d, J=8.1 Hz), 7.62 (1H, dd, J=5.0, 1.1 Hz), 1.28 (3H, t, J=7.3 Hz).

Workup

  1. temperatureIn a sealed tube were heated
  2. custompurified in a usual manner

Sources & evidence

ORD record
ord-d73dd9eee3b64802a799b1509bc40ebb
Source dataset
uspto-grants-2004_05
Patent number
US06740662B1

Linked notes

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