4-(3-Bromopropyl)pyridine → 4-(Pyridin-4-YL)butanenitrile
Reaction equation
[N:1]1[CH:6]=[CH:5][CH:4]=[C:3](CCCC#N)[CH:2]=1.[N:12]1C=[CH:16][C:15](CCCBr)=[CH:14][CH:13]=1>>[N:1]1[CH:2]=[CH:3][C:4]([CH2:16][CH2:15][CH2:14][C:13]#[N:12])=[CH:5][CH:6]=1Participants
3
Procedure
4-Pyridinebutanenitrile was prepared according to the procedure employed in the synthesis of 3-pyridinebutanenitrile. From 73.1 g of the hydrobromide salt of 3-(4-pyridyl)propyl bromide there was obtained 19.35 g (51%) of 4-pyridinebutanenitrile, bp 140°-141° C./2.0 mm.
Workup
- custom4-Pyridinebutanenitrile was prepared
Sources & evidence
- ORD record
- ord-3d9c6b16619c4c32aaa22dcaaf800499
- Source dataset
- uspto-grants-1985_11
- Patent number
- US04551460
Reaction notes
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