1-Butanol → HCID 178454803, compound

HRID 1583731

Reaction equation

HRID 1583731 reaction equation
[OH:1][CH:2]([PH:4](=[O:6])[OH:5])[CH3:3].[CH2:7](O)[CH2:8][CH2:9][CH3:10].O>C1C=CC=CC=1>[OH:1][CH:2]([PH:4](=[O:5])[O:6][CH2:7][CH2:8][CH2:9][CH3:10])[CH3:3]

Participants

5

Reactant 3

HCID 2631-ButanolHCID 962WaterHCID 178476830HCID 178476830, compound

Product 1

HCID 178454803HCID 178454803, compoundYield 81.6%

Reagents, catalysts & solvents 1

HCID 241BenzeneSolvent

Procedure

A solution of α-hydroxyethylphosphinic acid (2.2 g) and 1-butanol (5.0 g) in benzene (30 ml) was heated for 3 hours with removal of water through a Dean-Stark apparatus. After cooling, the reaction mixture was washed with water, dried over magnesium sulfate and concentrated in vacuo to give 2.71 g (81.6%) of n-butyl α-hydroxyethylphosphinate (Compound No. 5).

Workup

  1. temperatureAfter cooling
  2. washthe reaction mixture was washed with water
  3. dry with materialdried over magnesium sulfate
  4. concentrationconcentrated in vacuo

Sources & evidence

ORD record
ord-b4d1c7115b5d49439144f548dd9ea9fa
Source dataset
uspto-grants-1985_11
Patent number
US04554111

Linked notes

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