Methylhydrazine → 3(2H)-Pyridazinone, 6-(4-chlorophenyl)-4,5-dihydro-2-methyl-

HRID 1584

Reaction equation

HRID 1584 reaction equation
[Cl:1][C:2]1[CH:14]=[CH:13][C:5]([C:6]([CH2:8][CH2:9][C:10](O)=[O:11])=O)=[CH:4][CH:3]=1.[CH3:15][NH:16][NH2:17]>C(O)C>[Cl:1][C:2]1[CH:14]=[CH:13][C:5]([C:6]2[CH2:8][CH2:9][C:10](=[O:11])[N:16]([CH3:15])[N:17]=2)=[CH:4][CH:3]=1

Participants

4

Reactant 2

HCID 6061MethylhydrazineHCID 776043-(4-Chlorobenzoyl)propionic acid

Product 1

HCID 121965643(2H)-Pyridazinone, 6-(4-chlorophenyl)-4,5-dihydro-2-methyl-

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

To a 250 ml flask equipped with magnetic stirrer and reflux condenser was charged 10 g of 3-(4-chlorobenzoyl)-propionic acid, 250 ml. of absolute ethanol, and 2.5 ml of methyl hydrazine. The reaction was refluxed for 3 hours and cooled to yield a solid which was collected by vacuum filtration, washed with 50 ml of hexane, and air dried. Isolated 9.5 g of product as a white solid.

Workup

  1. customTo a 250 ml flask equipped with magnetic stirrer
  2. temperaturereflux condenser
  3. temperatureThe reaction was refluxed for 3 hours
  4. temperaturecooled
  5. customto yield a solid which
  6. filtrationwas collected by vacuum filtration
  7. washwashed with 50 ml of hexane, and air
  8. customdried

Sources & evidence

ORD record
ord-b13d649eb0e543419a54c9aec5175c91
Source dataset
uspto-grants-1998_03
Patent number
US05726176

Linked notes

Loading…