Acetonitrile → 2-Methylquinazoline

HRID 1584136

Reaction equation

[NH2:1][C:2]1[CH:15]=[CH:14][CH:13]=[CH:12][C:3]=1[C:4](C1C=CC=CC=1)=O.[C:16](#[N:18])[CH3:17]>>[CH3:17][C:16]1[N:18]=[CH:4][C:3]2[C:2](=[CH:15][CH:14]=[CH:13][CH:12]=2)[N:1]=1

Participants

Reactant 2

HCID 6342Acetonitrile

HCID 760802-Aminobenzophenone

Product 1

HCID 5889872-Methylquinazoline

Procedure

In this method, 2-aminobenzophenone derivative (IV) is reacted with acetonitrile to yield 2-methylquinazoline derivative (IX), which is then brominated to 2-bromomethylquinazoline derivative (II-4). The reaction of compound (IV) and acetonitrile is carried out in the same manner as method D. Bromination of compound (IX) is carried out in the same manner as the bromination of compound (VII) by method C.

Sources & evidence

ORD record: ord-2154f7d610e34b06b569829eff29d7de
Source dataset: uspto-grants-1999_08
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US05932592

Linked notes

Loading…