2-Oxazolidinone → 3-[3-(2-Hydroxyethyl)phenyl]-1,3-oxazolidin-2-one

HRID 15853

Reaction equation

Br[C:2]1[CH:3]=[C:4]([CH2:8][CH2:9][OH:10])[CH:5]=[CH:6][CH:7]=1.[O:11]1[CH2:15][CH2:14][NH:13][C:12]1=[O:16]>>[OH:10][CH2:9][CH2:8][C:4]1[CH:3]=[C:2]([N:13]2[CH2:14][CH2:15][O:11][C:12]2=[O:16])[CH:7]=[CH:6][CH:5]=1

Participants

Reactant 2

HCID 739492-Oxazolidinone

HCID 27340902-(3-Bromophenyl)ethan-1-ol

Product 1

HCID 542438113-[3-(2-Hydroxyethyl)phenyl]-1,3-oxazolidin-2-oneYield 48%

Procedure

The title compound was prepared in 48% yield according to the general procedure for the preparation of amides, ureas and carbamates (Method A) starting from 2-(3-bromophenyl)ethanol and 1,3-oxazolidin-2-one.

Sources & evidence

ORD record: ord-5df36ceb506846df86786bb67c718a03
Source dataset: uspto-grants-2010_06
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07732600B2

Linked notes

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