2-Methyl-5-[(3R)-3-methyl-1-piperazinyl]quinoline → 3-(3-{2-[(2R)-2-Methyl-4-(2-methyl-5-quinolinyl)-1-piperazinyl]ethyl}phenyl)-1,3-oxazolidin-2-one

HRID 15855

Reaction equation

HRID 15855 reaction equation
[CH3:1][C:2]1[CH:11]=[CH:10][C:9]2[C:4](=[CH:5][CH:6]=[CH:7][C:8]=2[N:12]2[CH2:17][CH2:16][NH:15][C@H:14]([CH3:18])[CH2:13]2)[N:3]=1.CS(O[CH2:24][CH2:25][C:26]1[CH:31]=[CH:30][CH:29]=[C:28]([N:32]2[CH2:36][CH2:35][O:34][C:33]2=[O:37])[CH:27]=1)(=O)=O>>[CH3:18][C@@H:14]1[CH2:13][N:12]([C:8]2[CH:7]=[CH:6][CH:5]=[C:4]3[C:9]=2[CH:10]=[CH:11][C:2]([CH3:1])=[N:3]3)[CH2:17][CH2:16][N:15]1[CH2:24][CH2:25][C:26]1[CH:27]=[C:28]([N:32]2[CH2:36][CH2:35][O:34][C:33]2=[O:37])[CH:29]=[CH:30][CH:31]=1

Participants

3

Reactant 2

HCID 574443392-Methyl-5-[(3R)-3-methyl-1-piperazinyl]quinolineHCID 574443402-[3-(2-Oxo-1,3-oxazolidin-3-yl)phenyl]ethyl methanesulfonate

Product 1

HCID 113509143-(3-{2-[(2R)-2-Methyl-4-(2-methyl-5-quinolinyl)-1-piperazinyl]ethyl}phenyl)-1,3-oxazolidin-2-oneYield 33%

Procedure

The title compound was prepared in 33% yield using a similar procedure to E124 starting from 2-methyl-5-[(3R)-3-methyl-1-piperazinyl]quinoline and 2-[3-(2-oxo-1,3-oxazolidin-3-yl)phenyl]ethyl methanesulfonate.

Sources & evidence

ORD record
ord-1f47185a411245128ce3b237e6cafd16
Source dataset
uspto-grants-2010_06
Patent number
US07732600B2

Linked notes

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