1-(3-Chlorobenzyl)piperazine → 7-(4-Chlorophenyl)-4-[[4-[(3-chlorophenyl)methyl]-1-piperazinyl]acetyl]-4,5-dihydro-6-methylpyrazolo[1,5-a]pyrimidine-3-carbonitrile. dihydrochloride

HRID 1587785

Reaction equation

HRID 1587785 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]([CH2:8][N:9]2[CH2:14][CH2:13][NH:12][CH2:11][CH2:10]2)[CH:5]=[CH:6][CH:7]=1.[Cl:15][CH2:16][C:17]([N:19]1[CH2:24][C:23]([CH3:25])=[C:22]([C:26]2[CH:31]=[CH:30][C:29]([Cl:32])=[CH:28][CH:27]=2)[N:21]2[N:33]=[CH:34][C:35]([C:36]#[N:37])=[C:20]12)=[O:18]>>[ClH:1].[ClH:15].[Cl:32][C:29]1[CH:30]=[CH:31][C:26]([C:22]2[N:21]3[N:33]=[CH:34][C:35]([C:36]#[N:37])=[C:20]3[N:19]([C:17](=[O:18])[CH2:16][N:12]3[CH2:11][CH2:10][N:9]([CH2:8][C:4]4[CH:5]=[CH:6][CH:7]=[C:2]([Cl:1])[CH:3]=4)[CH2:14][CH2:13]3)[CH2:24][C:23]=2[CH3:25])=[CH:27][CH:28]=1

Participants

3

Reactant 2

HCID 7647271-(3-Chlorobenzyl)piperazineHCID 151010894-(Chloroacetyl)-7-(4-chlorophenyl)-4.5-dihydro-6-methylpyrazolo[1,5-a]pyrimidine-3-carbonitrile

Product 1

HCID 1317166737-(4-Chlorophenyl)-4-[[4-[(3-chlorophenyl)methyl]-1-piperazinyl]acetyl]-4,5-dihydro-6-methylpyrazolo[1,5-a]pyrimidine-3-carbonitrile. dihydrochloride

Procedure

The above compound was prepared by the reaction of 4-(3-chlorophenyl)methylpiperazine with the compound of Example 14 by the methods of Examples 16 then 77, mp 250° C. (with sintering).

Sources & evidence

ORD record
ord-bdfd618f33b14f19bb3411d118e80fcb
Source dataset
uspto-grants-1993_06
Patent number
US05219857

Linked notes

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