Acetic Acid → Methyl 3-thiophenecarboximidate

3-cyanothiophene (0.66 g, 6.0 mmol) was dissolved in methanol (6 ml), and sodium methoxide (0.03 g, 0.6 mmol) was added. The mixture was stirred at room temperature for 28 hours. After the reaction was completed, acetic acid (0.03 g, 0.6 mmol) was added to neutralize the reaction solution, and the solution was concentrated under reduced pressure. Diethyl ether (50 ml) was added to the concentrated residue, and insolubles were removed by filtration. The filtrate was concentrated under reduced pressure to give the crude product of methyl 3-thiophenecarboximidate.

1. concentrationthe solution was concentrated under reduced pressure
2. additionDiethyl ether (50 ml) was added to the concentrated residue, and insolubles
3. customwere removed by filtration
4. concentrationThe filtrate was concentrated under reduced pressure

ORD record

ord-3590761d0ce24a0bbe455d7267adbb5a

Source dataset

uspto-grants-1993_06

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US05223508