Methyl iodide → 2-Methyl-1-(5-chloro-2-morpholinophenyl)-3-(n-butyl)-2-thiopseudourea hydroiodide
Reaction equation
[CH2:1]([NH:5][C:6]([NH:8][C:9]1[CH:14]=[C:13]([Cl:15])[CH:12]=[CH:11][C:10]=1[N:16]1[CH2:21][CH2:20][O:19][CH2:18][CH2:17]1)=[S:7])[CH2:2][CH2:3][CH3:4].[CH3:22][I:23]>CC(C)=O>[IH:23].[CH3:22][S:7][C:6](=[N:5][CH2:1][CH2:2][CH2:3][CH3:4])[NH:8][C:9]1[CH:14]=[C:13]([Cl:15])[CH:12]=[CH:11][C:10]=1[N:16]1[CH2:21][CH2:20][O:19][CH2:18][CH2:17]1Participants
4
Reactant 2
Product 1
Reagents, catalysts & solvents 1
Procedure
A mixture of 1-(n-butyl)-3-(5-chloro-2-morpholinophenyl)thiourea (2.6 g), methyl iodide (1.4 g) and acetone (20 ml) was heated under reflux for 3 hours to give 2-methyl-1-(5-chloro-2-morpholinophenyl)-3-(n-butyl)-2-thiopseudourea hydroiodide (m.p. 130°-132° C.).