Ammonia → 1-(5-Chloro-2-morpholinophenyl)thiourea

Reaction equation

[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([N:11]2[CH2:16][CH2:15][O:14][CH2:13][CH2:12]2)=[C:6]([N:8]=[C:9]=[S:10])[CH:7]=1.[NH3:17]>>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([N:11]2[CH2:16][CH2:15][O:14][CH2:13][CH2:12]2)=[C:6]([NH:8][C:9]([NH2:17])=[S:10])[CH:7]=1

Participants

Reactant 2

HCID 222Ammonia

HCID 189520985-Chloro-2-morpholinophenyl isothiocyanate

Product 1

HCID 189522431-(5-Chloro-2-morpholinophenyl)thiourea

Procedure

Reaction of 5-chloro-2-morpholinophenyl isothiocyanate (10 g) with 33% alcoholic ammonia solution (60 ml) at room temperature for 14 hours gave 1-(5-chloro-2-morpholinophenyl)thiourea as a yellow solid (m.p. 174°-175° C.).

Sources & evidence

ORD record: ord-7becbf93c1af44f0bd6871e1b948fd45
Source dataset: uspto-grants-1993_06
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US05223498

Reaction notes

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