N-(2-Methoxyphenyl)-2-[(phenylmethyl)amino]acetamide → N-(2-Methoxyphenyl)-N'-(phenylmethyl)-1,2-ethanediamine

Reaction equation

[CH3:1][O:2][C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][C:4]=1[NH:9][C:10](=O)[CH2:11][NH:12][CH2:13][C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=1.[H-].[Al+3].[Li+].[H-].[H-].[H-]>>[CH3:1][O:2][C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][C:4]=1[NH:9][CH2:10][CH2:11][NH:12][CH2:13][C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=1

Participants

Reactant 2

HCID 14998796N-(2-Methoxyphenyl)-2-[(phenylmethyl)amino]acetamide

HCID 21226445Aluminium lithium hydride

Product 1

HCID 14998755N-(2-Methoxyphenyl)-N'-(phenylmethyl)-1,2-ethanediamine

Procedure

In a manner similar to Preparation 2, react N-(2-methoxyphenyl)-2-[(phenylmethyl)amino]acetamide (0.31 g, 1.1 mmol) with lithium aluminum hydride (0.09 g, 2.4 mmol) to obtain the title compound.

Workup

customIn a manner similar to Preparation 2

Sources & evidence

ORD record: ord-72e7ac07ef7147daa7381b0576a30523
Source dataset: uspto-grants-1993_06
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US05223623

Reaction notes

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