2,3-Dibromopropionamide → 4-[3-(Acetylamino)phenyl]-1-(phenylmethyl)-2-piperazinecarboxamide
Reaction equation
[C:1]1([CH2:7][NH:8][CH2:9][CH2:10][NH:11][C:12]2[CH:13]=[C:14]([NH:18][C:19](=[O:21])[CH3:20])[CH:15]=[CH:16][CH:17]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.Br[CH:23]([CH2:27]Br)[C:24]([NH2:26])=[O:25]>>[C:19]([NH:18][C:14]1[CH:13]=[C:12]([N:11]2[CH2:10][CH2:9][N:8]([CH2:7][C:1]3[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=3)[CH:23]([C:24]([NH2:26])=[O:25])[CH2:27]2)[CH:17]=[CH:16][CH:15]=1)(=[O:21])[CH3:20]Participants
3
Procedure
In a manner similar to Preparation 1, react N-[3-[[2-[(phenylmethyl)amino]ethyl]amino]phenyl]acetamide (25.6 g, 90.4 mmol) with 2,3-dibromopropanamide (41.8 g, 180.8 mmol) to obtain the title compound.
Workup
- customIn a manner similar to Preparation 1
Sources & evidence
- ORD record
- ord-5b14346412b84729a773c68a8ec45a96