2,3-Dibromopropionamide → 4-(3,5-Dimethoxyphenyl)-1-(phenylmethyl)-2-piperazinecarboxamide
Reaction equation
[CH3:1][O:2][C:3]1[CH:4]=[C:5]([NH:11][CH2:12][CH2:13][NH:14][CH2:15][C:16]2[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=2)[CH:6]=[C:7]([O:9][CH3:10])[CH:8]=1.Br[CH:23]([CH2:27]Br)[C:24]([NH2:26])=[O:25]>>[CH3:10][O:9][C:7]1[CH:6]=[C:5]([N:11]2[CH2:12][CH2:13][N:14]([CH2:15][C:16]3[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=3)[CH:23]([C:24]([NH2:26])=[O:25])[CH2:27]2)[CH:4]=[C:3]([O:2][CH3:1])[CH:8]=1Participants
3
Procedure
In a manner similar to Preparation 1, react N-(3,5-dimethoxyphenyl)-N'-(phenylmethyl)-1,2-ethanediamine with 2,3-dibromopropanamide to obtain the title compound.
Workup
- customIn a manner similar to Preparation 1
Sources & evidence
- ORD record
- ord-bcae608e9f52430eb6e8ce1272efe58c