Glycine → Glyphosate

Reaction equation

[NH2:1][CH2:2][C:3]([OH:5])=[O:4].[CH:6]([P:8](=[O:11])([OH:10])[OH:9])=O.[H][H]>>[CH2:2]([NH:1][CH2:6][P:8]([OH:11])([OH:10])=[O:9])[C:3]([OH:5])=[O:4]

Participants

Reactant 3

HCID 750Glycine

HCID 10154022Formylphosphonic Acid

HCID 178418361HCID 178418361, compound

Product 1

HCID 3496GlyphosateYield 65.9%

Procedure

Reaction of glycine and formylphosphonic acid was carried out under the conditions of Example 2 except that the pH was initially adjusted to 8.0 and hydrogen gas was continuously bubbled through the liquid phase at atmospheric pressure. After 18 hours of reaction, a 65.9% yield of glyphosate was obtained.