Glycine → Glyphosate
Reaction equation
[CH:1]([P:3](=[O:6])([OH:5])[OH:4])=O.[NH2:7][CH2:8][C:9]([OH:11])=[O:10]>[Pd]>[CH2:8]([NH:7][CH2:1][P:3]([OH:4])([OH:5])=[O:6])[C:9]([OH:11])=[O:10]Participants
4
Reagents, catalysts & solvents 1
Procedure
Reaction of formylphosphonic acid and glycine was carried out in the manner described in Example 16 except that the catalyst was 1% palladium on alumina (0.5 g, 3.2 mm pellets). A 34% yield of glyphosate was obtained.
Sources & evidence
- ORD record
- ord-2037c9c108ac45baa65f71caf36f56b2
- Source dataset
- uspto-grants-1986_02
- Patent number
- US04568432
Reaction notes
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