Sulfuric Acid → 5-Amidino-2-hydroxybenzenesulfonic acid

HRID 1589494Notes

Reaction equation

HRID 1589494 reaction equation
[S:1](=[O:5])(=O)([OH:3])[OH:2].Cl.[C:7]([C:10]1[CH:15]=[CH:14][C:13]([OH:16])=[CH:12][CH:11]=1)(=[NH:9])[NH2:8]>>[C:7]([C:10]1[CH:11]=[CH:12][C:13]([OH:16])=[C:14]([S:1]([OH:3])(=[O:5])=[O:2])[CH:15]=1)(=[NH:8])[NH2:9]

Participants

3

Reactant 2

HCID 1118Sulfuric AcidHCID 217124Benzenecarboximidamide, 4-hydroxy-, hydrochloride (1:1)

Product 1

HCID 1355987485-Amidino-2-hydroxybenzenesulfonic acid

Procedure

To 15 ml of 60% fuming sulfuric acid, while being cooled in ice, was added slowly 10.0 g of 4-amidinophenol hydrochloride. After the addition, the mixture was stirred at room temperature for 4 hours, then poured slowly into 200 ml of ice water, and stirred for a while. The colorless solid which was precipitated was collected by filtration, washed with water, then with acetone, and dried to obtain 10.2 g of 5-amidino-2-hydroxybenzenesulfonic acid.

Workup

  1. additionAfter the addition
  2. stirringstirred for a while
  3. customThe colorless solid which was precipitated
  4. filtrationwas collected by filtration
  5. washwashed with water
  6. dry with materialwith acetone, and dried

Sources & evidence

ORD record
ord-998a82fd747b49988d27537fe1ff269a
Source dataset
uspto-grants-1986_02
Patent number
US04570006

Reaction notes

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