Ammonia → 4-Fluorobenzamidine Hydrochloride
Reaction equation
[NH3:1].[ClH:2].[F:3][C:4]1[CH:12]=[CH:11][C:7]([C:8](=[NH:10])O)=[CH:6][CH:5]=1>C(O)C>[ClH:2].[F:3][C:4]1[CH:12]=[CH:11][C:7]([C:8]([NH2:1])=[NH:10])=[CH:6][CH:5]=1Participants
4
Reactant 2
Product 1
Reagents, catalysts & solvents 1
Procedure
310 cm3 of ethanol saturated with ammonia was added to 83 g (0.41 mol) of 4-fluorobenzimidate hydrogen chloride and stirred at room temperature for one day and night. Approximately half of the ethanol was distilled off and the residue was recrystallized to yield 70 g (0.40 mol) of 4-fluorobenzamidine hydrogen chloride.
Workup
- distillationApproximately half of the ethanol was distilled off
- customthe residue was recrystallized
Sources & evidence
- ORD record
- ord-ae5e27fedda8416c8fa35477a79cebdf
- Source dataset
- uspto-grants-1993_04
- Patent number
- US05200110
Reaction notes
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