Isopropylamine → 2-Propanol, 1-[(1-methylethyl)amino]-3-(pyrazolo[1,5-a]pyridin-4-yloxy)-

Reaction equation

[N:1]1[N:5]2[CH:6]=[CH:7][CH:8]=[C:9]([O:10][CH2:11][CH:12]3[O:14][CH2:13]3)[C:4]2=[CH:3][CH:2]=1.[CH:15]([NH2:18])([CH3:17])[CH3:16]>>[CH:15]([NH:18][CH2:13][CH:12]([OH:14])[CH2:11][O:10][C:9]1[C:4]2[N:5]([N:1]=[CH:2][CH:3]=2)[CH:6]=[CH:7][CH:8]=1)([CH3:17])[CH3:16]

Participants

Reactant 2

HCID 6363Isopropylamine

HCID 152578983-(Pyrazolo[1,5-a]pyrid-4-yloxy)-1,2-epoxypropane

Product 1

HCID 98597622-Propanol, 1-[(1-methylethyl)amino]-3-(pyrazolo[1,5-a]pyridin-4-yloxy)-

Procedure

Then, the Compound (6) is reacted with isopropylamine to produce 1-(isopropylamino)-3-(pyrazolo[1,5-a]pyrid-4-yloxy)-2-propanol (A), with approximately quantitative yields being achieved.

Sources & evidence

ORD record: ord-2f2278aee9af4116bca5bf8da333b358
Source dataset: uspto-grants-1993_04
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US05202334

Reaction notes

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