1-Benzyl-5-methyloctahydropyrrolo[3,4-b]pyrrole → 5-Methyl-octahydropyrrolo(3,4-b)pyrrole
Reaction equation
C([N:8]1[CH2:15][CH2:14][CH:13]2[CH:9]1[CH2:10][N:11]([CH3:16])[CH2:12]2)C1C=CC=CC=1>C(O)C.[Pd]>[CH3:16][N:11]1[CH2:10][CH:9]2[CH:13]([CH2:14][CH2:15][NH:8]2)[CH2:12]1Participants
4
Reactant 1
Product 1
Reagents, catalysts & solvents 2
Procedure
10.3 g (47.6 mmol) of 2-benzyl-7-methyl-2,7-diazabicyclo[3.3.0]octane in 200 ml of ethanol are hydrogenated on 2.5 g of palladium/active carbon (10% Pd) at 100° C. and 100 bar. The catalyst is filtered off with suction, the filtrate is concentrated, and the residue is distilled.
Workup
- filtrationThe catalyst is filtered off with suction
- concentrationthe filtrate is concentrated
- distillationthe residue is distilled
Sources & evidence
- ORD record
- ord-67174bce212c493b97eedae3cd6532e9
- Source dataset
- uspto-grants-1993_04
- Patent number
- US05202337
Reaction notes
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