L-Leucine ethyl ester → HCID 131717875, compound

HRID 1590988

Reaction equation

HRID 1590988 reaction equation
[NH:1]([C:15]([O:17][C:18]([CH3:21])([CH3:20])[CH3:19])=[O:16])[C@H:2]([C:12]([OH:14])=O)[CH2:3][O:4][CH2:5][C:6]1[CH:11]=[CH:10][CH:9]=[CH:8][CH:7]=1.[NH2:22][C@H:23]([C:28]([O:30][CH2:31][CH3:32])=[O:29])[CH2:24][CH:25]([CH3:27])[CH3:26]>>[NH:1]([C:15]([O:17][C:18]([CH3:21])([CH3:20])[CH3:19])=[O:16])[C@H:2]([C:12]([NH:22][C@H:23]([C:28]([O:30][CH2:31][CH3:32])=[O:29])[CH2:24][CH:25]([CH3:27])[CH3:26])=[O:14])[CH2:3][O:4][CH2:5][C:6]1[CH:7]=[CH:8][CH:9]=[CH:10][CH:11]=1

Participants

3

Reactant 2

HCID 75971L-Leucine ethyl esterHCID 90234L-Serine, N-[(1,1-dimethylethoxy)carbonyl]-O-(phenylmethyl)-

Product 1

HCID 131717875HCID 131717875, compoundYield 69.1%

Procedure

By using 7.37 g of Boc-Ser(Bzl)-OH and 5.00 g of H-Leu-OEt, and the same procedure as in Reference Example 15 was repeated to obtain 7.53 g (yield: 69.1%) of the above-mentioned objective product.

Sources & evidence

ORD record
ord-b09735ccd5a047bdb535c6b5d6cfc4f6
Source dataset
uspto-grants-1993_04
Patent number
US05204326

Linked notes

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