Tert-butoxycarbonylalanine → Boc-Ala-Ser(Bzl)-Leu-OEt

HRID 1590989

Reaction equation

HRID 1590989 reaction equation
[NH:1]([C:25]([O:27]C(C)(C)C)=O)[C@H:2]([C:12]([NH:14][C@H:15]([C:20]([O:22][CH2:23][CH3:24])=[O:21])[CH2:16][CH:17]([CH3:19])[CH3:18])=[O:13])[CH2:3][O:4][CH2:5][C:6]1[CH:11]=[CH:10][CH:9]=[CH:8][CH:7]=1.[NH:32]([C:38]([O:40][C:41]([CH3:44])([CH3:43])[CH3:42])=[O:39])[C@H:33](C(O)=O)[CH3:34]>>[NH:32]([C:38]([O:40][C:41]([CH3:44])([CH3:43])[CH3:42])=[O:39])[C@H:33]([C:25]([NH:1][C@H:2]([C:12]([NH:14][C@H:15]([C:20]([O:22][CH2:23][CH3:24])=[O:21])[CH2:16][CH:17]([CH3:18])[CH3:19])=[O:13])[CH2:3][O:4][CH2:5][C:6]1[CH:7]=[CH:8][CH:9]=[CH:10][CH:11]=1)=[O:27])[CH3:34]

Participants

3

Reactant 2

HCID 85082Tert-butoxycarbonylalanineHCID 131717875Boc-Ser(Bzl)-Leu-OEt

Product 1

HCID 131717876Boc-Ala-Ser(Bzl)-Leu-OEtYield 82.9%

Procedure

By using 7.53 g of Boc-Ser(Bzl)-Leu-OEt and 3.50 g of Boc-Ala-OH, and the same procedure as in Reference Example 15 was repeated to obtain 7.26 g (yield: 82.9%) of the above-mentioned objective product.

Sources & evidence

ORD record
ord-b048f18203514903961167c30dc7ae9e
Source dataset
uspto-grants-1993_04
Patent number
US05204326

Linked notes

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