Sodium Hydroxide → 2-Acetyl-3-hydroxythiophene
Reaction equation
[C:1]([C:4]1[S:5][C:6](C(OC)=O)=[CH:7][C:8]=1[OH:9])(=[O:3])[CH3:2].[OH-].[Na+]>[Cu].N1C2C(=CC=CC=2)C=CC=1>[C:1]([C:4]1[S:5][CH:6]=[CH:7][C:8]=1[OH:9])(=[O:3])[CH3:2]Participants
4
Reactant 2
Product 1
Reagents, catalysts & solvents 1
Procedure
The above-obtained methyl 2-acetyl-3-hydroxythiophene-5-carboxylate was hydrolyzed with an aqueous solution of sodium hydroxide, the hydrolyzate was heated with copper-quinoline to be decarboxylated, thereby the objective 2-acetyl-3-hydroxythiophene was obtained (yield: 58%).
Sources & evidence
- ORD record
- ord-a347ccf5ee2649d3adda0b8311740e3e
- Source dataset
- uspto-grants-2007_11
- Patent number
- US07291449B2
Reaction notes
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