tert-butyl N-(4-aminobutyl)carbamate → {4-[(3,5-Dimethyl-pyridin-2-ylmethyl)-amino]-butyl}-carbamic acid tert-butyl ester

HRID 1592373

Reaction equation

HRID 1592373 reaction equation
[CH3:1][C:2]1[C:3]([CH:9]=O)=[N:4][CH:5]=[C:6]([CH3:8])[CH:7]=1.[C:11]([O:15][C:16](=[O:23])[NH:17][CH2:18][CH2:19][CH2:20][CH2:21][NH2:22])([CH3:14])([CH3:13])[CH3:12]>>[C:11]([O:15][C:16](=[O:23])[NH:17][CH2:18][CH2:19][CH2:20][CH2:21][NH:22][CH2:9][C:3]1[C:2]([CH3:1])=[CH:7][C:6]([CH3:8])=[CH:5][N:4]=1)([CH3:14])([CH3:12])[CH3:13]

Participants

3

Reactant 2

HCID 4351tert-butyl N-(4-aminobutyl)carbamateHCID 187316833,5-Dimethylpyridine-2-carbaldehyde

Product 1

HCID 58997221{4-[(3,5-Dimethyl-pyridin-2-ylmethyl)-amino]-butyl}-carbamic acid tert-butyl ester

Procedure

Colorless oil prepared from 3,5-dimethyl-pyridine-2-carbaldehyde and (4-amino-butyl)-carbamic acid tert-butyl ester 1H NMR (CDCl3) δ 1.43 (s, 9H), 1.53-1.60 (m, 4H), 2.27 (s, 6H), 2.65-2.75 (m, 2H), 3.10-3.16 (m, 2H), 3.83 (s, 2H), 4.76 (s, br, 1H), 7.24 (s, 1H), 8.21 (s, 1H).

Sources & evidence

ORD record
ord-d24b9480c0a64b46bf0c09d5a4c7a788
Source dataset
uspto-grants-2007_11
Patent number
US07291631B2

Linked notes

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