HCID 25248372, compound → HCID 19627217, compound
Reaction equation
[F:1][C:2]1[CH:7]=[C:6]([N+:8]([O-])=O)[CH:5]=[CH:4][C:3]=1[O:11][C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=1>CCO.[Pd]>[F:1][C:2]1[CH:7]=[C:6]([NH2:8])[CH:5]=[CH:4][C:3]=1[O:11][C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=1Participants
4
Reactant 1
Product 1
Reagents, catalysts & solvents 2
Procedure
2-Fluoro-4-nitro-1-phenoxybenzene and 7.2 g of 10% Pd/C were dissolved in 200 mL EtOH and stirred under 1 atmosphere of H2 overnight. The reaction mixture was filtered through Celite with the aid of 50 mL EtOH and concentrated to provide 3-fluoro-4-phenoxybenzenamine as an oil which was used in Step C without further purification.
Workup
- filtrationThe reaction mixture was filtered through Celite with the aid of 50 mL EtOH
- concentrationconcentrated
Sources & evidence
- ORD record
- ord-59ba03bb420749c99fbb16526e42678d
- Source dataset
- uspto-grants-2007_11
- Patent number
- US07294616B2
Reaction notes
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