Potassium tert-butoxide → 4-[(2S,5R)-2,5-dimethylpiperazin-1-yl]-2-fluoro-6-methoxybenzonitrile

Reaction equation

[CH3:1][C@H:2]1[CH2:7][NH:6][C@H:5]([CH3:8])[CH2:4][N:3]1[C:9]1[CH:16]=[C:15](F)[C:12]([C:13]#[N:14])=[C:11]([F:18])[CH:10]=1.C[C:20](C)([O-:22])C.[K+]>>[CH3:1][C@H:2]1[CH2:7][NH:6][C@H:5]([CH3:8])[CH2:4][N:3]1[C:9]1[CH:16]=[C:15]([O:22][CH3:20])[C:12]([C:13]#[N:14])=[C:11]([F:18])[CH:10]=1

Participants

Reactant 2

HCID 23665647Potassium tert-butoxide

HCID 686919624-[(2S,5R)-2,5-dimethylpiperazin-1-yl]-2,6-difluorobenzonitrile

Product 1

HCID 686911704-[(2S,5R)-2,5-dimethylpiperazin-1-yl]-2-fluoro-6-methoxybenzonitrile

Procedure

The compound was synthesized in the similar manner as in Reference Example 4-1 using 4-[(2S,5R)-2,5-dimethylpiperazin-1-yl]-2,6-difluorobenzonitrile and 1 equivalent of potassium tert-butoxide.

Sources & evidence

ORD record: ord-a0991420e7ee4ae0929b78f8c594acce
Source dataset: uspto-grants-2007_11
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07297698B2

Reaction notes

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