Bromine → 5-Bromo-2-hydroxypyridine-3-carbonitrile

HRID 1593669Notes

Reaction equation

HRID 1593669 reaction equation
[Br:1]Br.[O:3]=[C:4]1[C:9]([C:10]#[N:11])=[CH:8][CH:7]=[CH:6][NH:5]1>C(O)(=O)C>[Br:1][C:7]1[CH:8]=[C:9]([C:10]#[N:11])[C:4](=[O:3])[NH:5][CH:6]=1

Participants

4

Reactant 2

HCID 24408BromineHCID 5775433-Cyano-2-pyridone

Product 1

HCID 72048705-Bromo-2-hydroxypyridine-3-carbonitrile

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Procedure

Bromine (29 ml, 560 mmol) was added to a stirred solution of 2-oxo-1,2-dihydro-pyridine-3-carbonitrile (34 g, 280 mmol) in acetic acid (180 ml) at room temperature. After 14 hours the reaction mixture was concentrated in vacuo and the resulting oil was trituated with ethanol to afford the title compound as a solid.

Workup

  1. concentrationAfter 14 hours the reaction mixture was concentrated in vacuo

Sources & evidence

ORD record
ord-bad87c6cf601468b882f553d00f8474a
Source dataset
uspto-grants-2007_11
Patent number
US07297792B2

Reaction notes

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